Table 4. In silico annotation of eQTLs.

CHR	BP	SNP	lead SNP Position	eQTL gene symbol	Gene Description	Distancefrom SNP (kb)	eQTL Cell type	TF	DHS	Histon Modification
Fasting glucose (GLU0)
11	61354548	rs1535	Intron ofFADS2	FADS1	Fatty acid desaturase 1	26,5	Lymphoblastoid	O	O	O
				NXF1	Nuclear RNAexport factor 1	968.0
6	33352694	rs463302	3′ flanking ofB3GALT4	B3GALT4	UDP-Gal:betaGlcNAcbeta 1,3-galactosyltransferase,polypeptide 4	0.2	Cerebellum	O	O	O
6	56726719	rs3002007	Intron of DST	RAB23	RAB23, member RASoncogene family	360.3	Monocytes	O	O	O
1	212214869	rs1431985	upstream ofAK092251	TRAF5	TNF receptor-associatedfactor 5	666.5	Liver	O		O
Gamma-glutamyl transpeptidase (GGT)
12	119889509	rs2251468	downstream ofHNF1A-AS1	C12orf43	Chromosome 12 openreading frame 43	37.0	Monocytes		O	O
12	109839709	rs11065774	Intron ofMYL2	MYL2	Myosin lightchain 2	-	Lymphoblastoid	O	O	O
7	72609167	rs13233571	Intron ofBCL7B	TBL2	transducin(beta)-like 2	383.8	Lymphoblastoid	O	O	O
Total cholesterol (Tchol)
2	27596658	rs780092	Intron ofGCKR	XAB1	XPA bindingprotein 1, GTPase	277.1	Lymphoblastoid			O
5	74844636	rs4604177	Intron ofPOLK	FAM169A	Family with sequencesimilarity 169	617.1	Lymphoblastoid		O	O
Low density lipoprotein cholesterol (LDLC)
12	109839709	rs11065774	Intron ofMYL2	MYL2	Myosin lightchain 2	-	Lymphoblastoid	O	O	O
18	59728271	rs9966367	Intron ofSERPINB10	SERPINB10	serpin peptidase inhibitor,clade B (ovalbumin), member 10	44.1	Lymphoblastoid	O	O	O
5	74844636	rs4604177	Intron ofPOLK	FAM169A	Family with sequencesimilarity 169	617.1	Lymphoblastoid		O	O
Triglyceride (TG)
8	19864713	rs12679834	Intron ofLPL	LPL	Lipoproteinlipase	-	Monocytes		O	O
11	116167789	rs651821	5′ UTR ofAPOA5	TAGLN	Transgelin	412.9	Monocytes	O	O	O

Note. CHR: chromosome, BP: base position based on the human genome (NCBI36/hg18), SNP: single-nucleotide polymorphism, eQTL: expression quantitative trait loci, TF: Transcription factor binding in liver or pancreas cells, DHS: DNase1 Hypersensitive site in liver or pancreas cells.