Table 4. Maternal Grand Multiparity and Severe Mental Disorders in the Offspring.
| All Participants | Women | Men | ||||
| Diagnostic outcome | HRa (95% CI)b | p | HRa (95% CI)b | p | HRa (95% CI)b | p |
| Any Mental Disorder | ||||||
| Model 1c | 1.13 (0.84–1.51) | 0.42 | 1.74 (1.15–2.64) | 0.01 | 0.83 (0.55–1.25) | 0.37 |
| Model 2d | 1.17 (0.87–1.58) | 0.30 | 1.79 (1.16–2.77) | 0.01 | 0.87 (0.57–1.32) | 0.50 |
| Substance Use Disorders | ||||||
| Model 1c | 1.07 (0.71–1.60) | 0.76 | 2.00 (0.97–4.13) | 0.06 | 0.86 (0.53–1.40) | 0.54 |
| Model 2d | 1.15 (0.76–1.73) | 0.52 | 2.07 (0.97–4.41) | 0.06 | 0.94 (0.57–1.54) | 0.80 |
| Psychotic Substance Use Disorders | ||||||
| Model 1c | 0.75 (0.33–1.71) | 0.50 | 0.80 (0.11–5.85) | 0.83 | 0.73 (0.30–1.79) | 0.49 |
| Model 2d | 0.81 (0.35–1.85) | 0.61 | 0.75 (0.10–5.70) | 0.78 | 0.81 (0.32–2.01) | 0.64 |
| Non-Psychotic Substance Use Disorders | ||||||
| Model 1c | 1.22 (0.77–1.94) | 0.40 | 2.56 (1.17–5.60) | 0.02 | 0.92 (0.51–1.64) | 0.78 |
| Model 2d | 1.33 (0.82–2.14) | 0.24 | 2.77 (1.21–6.34) | 0.02 | 1.01 (0.56–1.82) | 0.98 |
| Schizophrenia, Schizotypal, and Delusional Disorders | ||||||
| Model 1c | 1.44 (0.80–2.59) | 0.22 | 2.43 (1.17–5.03) | 0.02 | 0.81 (0.30–2.22) | 0.68 |
| Model 2d | 1.49 (0.81–2.73) | 0.20 | 2.40 (1.12–5.16) | 0.02 | 0.87 (0.31–2.42) | 0.79 |
| Mood Disorders | ||||||
| Model 1c | 1.51 (0.99–2.32) | 0.06 | 2.04 (1.18–3.52) | 0.01 | 1.07 (0.54–2.10) | 0.84 |
| Model 2d | 1.64 (1.06–2.54) | 0.03 | 2.40 (1.36–4.23) | 0.002 | 1.07 (0.53–2.14) | 0.86 |
| Psychotic Mood Disorders | ||||||
| Model 1c | 0.30 (0.04–2.16) | 0.23 | 0.66 (0.09–4.82) | 0.68 | 0 (NA) | 0.97 |
| Model 2d | 0.32 (0.04–2.33) | 0.26 | 0.73 (0.10–5.46) | 0.76 | 0 (NA) | 0.97 |
| Non-Psychotic Mood Disorders | ||||||
| Model 1c | 1.87 (1.20–2.89) | 0.01 | 2.44 (1.38–4.34) | 0.002 | 1.36 (0.69–2.69) | 0.38 |
| Model 2d | 2.02 (1.28–3.19) | 0.002 | 2.91 (1.61–5.27) | <0.001 | 1.35 (0.67–2.74) | 0.40 |
| Anxiety Disorders | ||||||
| Model 1c | 0.63 (0.26–1.54) | 0.31 | 0.57 (0.14–2.33) | 0.44 | 0.68 (0.21–2.18) | 0.52 |
| Model 2d | 0.62 (0.25–1.55) | 0.31 | 0.54 (0.13–2.25) | 0.40 | 0.71 (0.22–2.30) | 0.56 |
| Personality Disorders | ||||||
| Model 1c | 1.06 (0.43–2.61) | 0.90 | 1.09 (0.26–4.48) | 0.91 | 1.05 (0.33–3.37) | 0.94 |
| Model 2d | 1.09 (0.43–2.75) | 0.86 | 1.10 (0.26–4.68) | 0.89 | 1.08 (0.32–3.61) | 0.90 |
| Suicides | ||||||
| Model 1c | 0.30 (0.04–2.20) | 0.24 | 0 (NA) | 0.98 | 0.39 (0.05–2.81) | 0.35 |
| Model 2d | 0.31 (0.04–2.29) | 0.25 | 0 (NA) | 0.99 | 0.38 (0.05–2.83) | 0.35 |
| Suicide Attempts | ||||||
| Model 1c | 3.34 (1.32–8.47) | 0.01 | 3.84 (1.15–12.86) | 0.03 | 2.82 (0.65–12.17) | 0.16 |
| Model 2d | 3.94 (1.49–10.39) | 0.01 | 5.05 (1.44–17.73) | 0.01 | 2.95 (0.64–13.60) | 0.17 |
| Organic Dementias | ||||||
| Model 1c | 0.93 (0.29–2.98) | 0.91 | 0.73 (0.10–5.40) | 0.76 | 1.07 (0.25–4.45) | 0.93 |
| Model 2d | 1.09 (0.34–3.55) | 0.88 | 0.79 (0.10–6.05) | 0.82 | 1.32 (0.31–5.62) | 0.70 |
a
HR = Hazard Ratio.
b
CI = Confidence Interval.
c
Stratified for sex and year of birth and adjusted for mother’s and father’s highest attained occupational statuses, birth weight of the offspring, and maternal body mass index at childbirth.
d
Stratified for sex and year of birth and adjusted for mother’s and father’s highest attained occupational statuses, birth weight of the offspring, maternal body mass index at childbirth, and maternal age at childbirth.