Table 3. Geographical polymorphism in the Der p 1 allergen.
Locality and DNA template | Most frequently reported mutation sites | Other sporadic mutation sites | Reference | |||
Y50 | V124 | T136 | Q215 | |||
Pakistan genomic | - | V/A | S | E | None | This study |
USA genomic | Y/H | A | - | - | None | This study |
UK genomic | - | A | S | n.r. | None | Kent et al., 1992 |
Sydney genomic | - | V/A | S/T | E | None | Smith et al., 2001 |
Melbourne cDNA | H/Y | V/A | S/T | E/Q | 1 | Chua et al., 1993 |
Perth cDNA | - | V/A | S | E/K | 6 | Smith et al., 2001 |
Bangkok cDNA | H/Y | A/V | S | E/G | 9 | Piboonpocanun et al., 2006 |
Korea cDNA | Y/H | V/A | S | E | 20 | Jeong et al., 2012 |
Superscript on amino acid symbol indicates the position in polypeptide (N.R.: not reported; “a.a/a.a”: higher frequency/lower frequency reported; “-”: no mutation