Table II.

Non-synonymous variants identified in NLRP2 in cases of primary infertility or RPL.

Exon	Nucleotide change	Protein change	dbSNP		MAF Score (Minor Allele)
			ID	MAF (Minor Allele)	Unexplained infertility	RPL
2	c.11C>T	p.S4L	rs142463014	Unavailable	0.005(T)	0.0208(T)
2	c.15G>A	p.A5A	rs269912	0.122(A)	0.191(A)	0.1875(A)
2	c.175C>T	p.L59F	rs150097185	Unavailable	0.005(T)	—
3	c.312G>A	p.K104K	rs2217659	0.214(A)	0.154(A)	0.1875(A)
4	c.361G>A	p.D121A	Novel	Unavailable	0.005(A)	—
6	c.519C>T	p.F172F	rs10403648	0.145(T)	0.042(T)	0.0417(T)
6	c.596C>T	p.T198M	rs17699678	0.061(T)	0.313(T)	0.1041(T)
6	c.715C>T	p.L239L	rs56073572	0.047(T)	0.138(T)	0.1041(T)
6	c.979G>C	p.E327Q	rs148817929	Unavailable	0.010(C)	—
6	c.982G>C	p.E328Q	rs142528551	Unavailable	0.010(C)	—
6	c.1010G>A	p.R337Q	rs149735961	Unavailable	0.0157(A)	0.0208(A)
6	c.1009T>C	p.F337L	rs62124644	0.005(C)	0.005(C)	0.0208(C)
6	c.1056C>T	p.D352D	rs3826883	0.144(T)	0.207(C)	0.2291(C)
6	c.1072C>T	p.R358C	rs189403101	Unavailable	0.005(T)	—
6	c.1480A>G	p.T494A	rs61735082	Unavailable	0.015(G)	0.0208(G)
6	c.1500A>G	p.E500E	rs3745905	0.149(G)	0.047(G)	0.0208(G)
6	c.1499A>G	p.E500G	rs61735083	Unavailable	0.015	0.0625
6	c.1506T>C	p.D502D	rs61735084	0.009(C)	0.015(C)	0.0208(C)
6	c.1519A>G	p.T507A	rs34804158	0.160(G)	0.212(G)	0.25(G)
6	c.1608T>C	p.F536F	rs10412915	0.306(C)	0.313(C)	0.3125(C)
6	c.1749C>G	p.L583L	rs11672113	0.293(G)	0.382(G)	0.375(G)
7	c.2044C>T	p.L704L	rs61733928	0.018(T)	0.026(T)	—
13	c.2994C>A	p.I1020I	rs12768	0.442(C)	0.558(C)	0.5208(C)
13	c.3089C>A	p.A1052E	rs1043673	0.359(A)	0.367(A)	0.3958(A)

SNP not found in the study group.

MAF, minor allele frequency.