Figure 5.

As₄S₄ inhibited tumor growth and elevated the levels of IL-2 in the tumor-bearing C57BL/6 mice. (A) Tumor weight reduced significantly following treatment with 60 mg/kg (H) of As₄S₄, but the reduction observed was not significant with 30 mg/kg (L). (B) Levels of IL-2 were significantly elevated in the treatment groups compared with the NC group. Data are expressed as the mean ± standard deviation; ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. NC. As₄S₄, arsenic sulfide; IL-2, interleukin 2; L, low; H, high; NC, negative control; CTX, cyclophosphamide.