Table III.
SNAP-25 in different layers of each subfield in the hippocampus.
| Subfield | Stratum | C | Hypo | DON | T4 | T4+DON |
|---|---|---|---|---|---|---|
| CA1 | SO | 3.55±0.11 | 4.82±0.08** | 4.49±1.13** | 4.39±0.05** | 3.80±0.12 |
| SR | 3.72±0.15 | 4.64±0.14** | 4.43±0.18** | 4.34±0.12* | 4.16±0.13 | |
| SLM | 3.52±0.11 | 4.36±0.12** | 4.26±0.09** | 4.00±0.12* | 3.77±0.11 | |
| CA3 | SO | 4.07±0.06 | 5.04±0.10** | 5.02±0.10** | 4.83±0.06** | 4.40±0.11 |
| SL | 3.63±0.12 | 4.10±0.12 | 4.09±0.15 | 3.92±0.11 | 4.07±0.09 | |
| SR | 3.67±0.14 | 4.36±0.09** | 4.29±0.12** | 3.95±0.09 | 3.80±0.09 | |
| DG | ML | 3.61±0.10 | 4.69±0.13** | 4.57±0.06** | 4.00±0.09 | 3.81±0.09 |
| PL | 3.66±0.11 | 4.75±0.04** | 4.46±0.09** | 3.95±0.06 | 3.85±0.05 |
Data (the mean ± SEM) are expressed as the average OD of SNAP-25 immunoreactivity (n=10–12). C, control group; Hypo, hypothyroid group; DON, hypothyroid rats treated with 0.005% (w/v) DON; T4, hypothyroid rats treated with 6 μg T4/100 g BW; T4+DON, hypothyroid rats treated with 6 μg T4/100 g body weight beside adding 0.005% (w/v) donepezil to the drinking water.
*
P<0.05,
**
P<0.01, vs. C.
SNAP-25, synaptosomal-associated protein of 25 kDa; DG, dentate gyrus; SO, stratum oriens; SR, stratum radiatum; SLM, stratum lacunosum-moleculare; SL, stratum lucidum; ML, molecular layer; PL, polymorphic layer; OD, optical density; w/v, weight/volume.