Table III.
Effect of APE on MDA levels, and SOD and GSH-Px activities in liver homogenates of CCl4-induced liver fibrosis in rats (n=10).
| Group | Dose (g/kg) | GSH-Px (U/mg) | SOD (U/mg) | MDA (μmol/g) |
|---|---|---|---|---|
| Normal | — | 397.85±54.58 | 247.62±41.82 | 42.16±9.86 |
| Model | — | 215.51±42.43a | 146.83±28.68a | 71.83±11.35a |
| APE | 1.3 | 246.25±31.46 | 161.52±30.49 | 62.83±12.63 |
| 2.6 | 265.31±32.46b | 183.64±29.34b | 56.83±12.64b | |
| 5.2 | 297.61±34.56c | 195.39±32.94b | 52.61±13.48b | |
| Colchicine | 0.1 | 271.68±31.83b | 174.22±28.57b | 58.23±15.61 |
Values are expressed as the mean ± standard deviation.
a
P<0.01 compared with control group;
b
P<0.05,
c
P<0.01 compared with model group.
APE, Astragalus and Paeoniae radix rubra extract; GSH-Px, glutathione; SOD, superoxide dismutase; MDA, malondialdehyde.