Table I.
Summary of methylated miRNAs in GC.
| miRNA | Expression levels in GC tissues | Target genes | References |
|---|---|---|---|
| miR-124a-1-3 | Downregulated | - | (39) |
| miR-34b/c | Downregulated | CDK4, MET, CCNE2 | (40,41) |
| miR-181c | Upregulated/downregulated | NOTCH4, KRAS | (42) |
| miR-137 | Downregulated | Cdc42 | (45) |
| miR-9 | Downregulated | NF-κB1, RAB34 | (47–49) |
| miR-212 | Downregulated | MYC, MeCP2 | (50) |
| miR-148a | Downregulated | DNMT1, ROCK1 | (52,53) |
| miR-10b | Downregulated | MAPRE1 | (58) |
| miR-195 | Downregulated | CDK6 | (60) |
| miR-378 | Downregulated | VEGF | (60) |
| miR-196b | Upregulated | - | (16) |
| miR-512-5p | Downregulated | MCL1 | (63) |
| miR-219-2-3p | Downregulated | - | (64) |
| miR-338-3p | Downregulated | SSX2IP | (65) |
miRNA, microRNA; GC, gastric cancer; CDK4, cyclin-dependent kinase 4; MET, hepatocyte growth factor receptor; CCNE2, cyclin E2; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Cdc42, cell division cycle 42; DNMT1, DNA methyltransferase 1; ROCK1, Rho-associated protein kinase 1; MAPRE1, microtuble-associated protein RP/EB family member 1; CDK6, cyclin-dependent kinase 6; VEGF, vascular endothelial growth factor; RAB34, member of RAS oncogene family; MeCP2, methyl CpG binding protein 2; SSX2IP, synovial sarcoma X breakpoint protein.