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. Author manuscript; available in PMC: 2014 Dec 10.
Published in final edited form as: Clin Cancer Res. 2010 Apr 6;16(8):2466–2473. doi: 10.1158/1078-0432.CCR-09-3015

Table 3.

Toxicity

Dose level 1
(6 mg/m2), n = 28
 Dose level 2
(7.5 mg/m2), n = 8
Grade 3–4
 Grade 3–4
n (%) n (%)
Any events 21 (75.0) 7 (87.5)
Nonhematologic adverse event
  Fatigue 2 (7.1) 0 (0.0)
  Nausea 1 (3.6) 0 (0.0)
  Constipation 1 (3.6) 1 (12.5)
  Diarrhea 1 (3.6) 0 (0.0)
  Cough 1 (3.6) 0 (0.0)
  Vomiting 2 (7.1) 0 (0.0)
  Neuropathy 2 (7.1) 0 (0.0)
Sensory
  Hyponatremia 0 (0.0) 2 (25.0)
  Dehydration 1 (3.6) 0 (0.0)
  Neuropathy 1 (3.6) 0 (0.0)
Hematologic adverse event
  Neutropenia 12 (42.9) 6 (75.0)
  Leucopenia 4 (14.3) 1 (12.5)