Table 1.

Potential Prognostic Value of Postn Overexpression in Human ICC and Other GI Cancers After Surgical Resection

Study Site	Tum or Type a	No Cases Analyzed	% Tumors with Strong Postn Expression	Compartment d	Endpoint e	Statistics	Result	Reference
Switzerland	BDC	116b	67.2 33.6	S C	OS	Kaplan-Meier, Multivariate Cox analysis	High C, but not S, Postn expression independent prognostic factor for reduced OS (P=0.033)	[52]
Thailand	ICC	52	58 0	S C	OS	Kaplan-Meier, Multivariate Cox analysis	High S Postn expression independent prognostic factor for shorter OS times (P=0.026)	[43]
Switzerland	HCC	91	11 20.9	S C	OS	Kaplan-Meier	No significant correlation between Postn expression and OS	[52]
P.R. China	HCC	71	73.2c 19.7	C PC	OS DFS	Kaplan-Meier, Multivariate Cox analysis	High Postn positive expression independent prognostic factor for OS and DFS rates (P=0.001)	[53]
Germany	PDAC	41	100 0	S C	OS	Kaplan-Meier	Tumors with increased Postn mRNA levels had a tendency towards shorter median survival times (P=0.14)	[30]
P.R. China	PDAC	94	80 30	S C	OS	Kaplan-Meier	Elevated expression of Postn in S as well as in C associated with poorer OS rates (P=0.035 and 0.022, respectively)	[54]
P.R. China	ESCC	68	73.5	C	OS DSF	Kaplan-Meier, Multivariate Cox analysis	Postn expression independent predictor of poor prognosis for both OS and DFS (P=0.027 and 0.026, respectively)	[55]
P.R. China	CRC	720	30.28	C	OS	Kaplan-Meier, Multivariate Cox analysis	Postn expression independent prognostic factor for post- operative liver metastasis (P=0.001) and poor prognosis for OS (P=0.001)	[56]

^aBDC, bile duct carcinomas; ICC, intrahepatic cholangiocarcinoma; HCC, hepatocellular carcinoma; PDAC, pancreatic ductal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; CRC, colorectal adenocarcinoma

^bSurvival data available for 111 patients

^cPostn expression scored only as positive or negative

^dS, stromal cell; C, cancer cell; PC, paracarcinomatous tissue

^eOS, overall survival; DFS, disease free survival