Table 1.
Study Site |
Tum or Type a |
No Cases Analyzed |
% Tumors with Strong Postn Expression |
Compartment d |
Endpoint e |
Statistics |
Result | Reference |
---|---|---|---|---|---|---|---|---|
Switzerland | BDC | 116b | 67.2 33.6 |
S C |
OS | Kaplan-Meier, Multivariate Cox analysis | High C, but not S, Postn expression independent prognostic factor for reduced OS (P=0.033) | [52] |
Thailand | ICC | 52 | 58 0 |
S C |
OS | Kaplan-Meier, Multivariate Cox analysis | High S Postn expression independent prognostic factor for shorter OS times (P=0.026) | [43] |
Switzerland | HCC | 91 | 11 20.9 |
S C |
OS | Kaplan-Meier | No significant correlation between Postn expression and OS | [52] |
P.R. China | HCC | 71 | 73.2c 19.7 |
C PC |
OS DFS |
Kaplan-Meier, Multivariate Cox analysis | High Postn positive expression independent prognostic factor for OS and DFS rates (P=0.001) | [53] |
Germany | PDAC | 41 | 100 0 |
S C |
OS | Kaplan-Meier | Tumors with increased Postn mRNA levels had a tendency towards shorter median survival times (P=0.14) | [30] |
P.R. China | PDAC | 94 | 80 30 |
S C |
OS | Kaplan-Meier | Elevated expression of Postn in S as well as in C associated with poorer OS rates (P=0.035 and 0.022, respectively) | [54] |
P.R. China | ESCC | 68 | 73.5 | C | OS DSF |
Kaplan-Meier, Multivariate Cox analysis | Postn expression independent predictor of poor prognosis for both OS and DFS (P=0.027 and 0.026, respectively) | [55] |
P.R. China | CRC | 720 | 30.28 | C | OS | Kaplan-Meier, Multivariate Cox analysis | Postn expression independent prognostic factor for post- operative liver metastasis (P=0.001) and poor prognosis for OS (P=0.001) | [56] |
BDC, bile duct carcinomas; ICC, intrahepatic cholangiocarcinoma; HCC, hepatocellular carcinoma; PDAC, pancreatic ductal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; CRC, colorectal adenocarcinoma
Survival data available for 111 patients
Postn expression scored only as positive or negative
S, stromal cell; C, cancer cell; PC, paracarcinomatous tissue
OS, overall survival; DFS, disease free survival