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Comparison of enthalpic (ΔH) and entropic (TΔS) contributions to the overall free energy of ligand binding to WW domains alone and in the context of WW1-WW2 tandem module of YAP2 to various cognate peptides in terms of the TΔS/ΔH ratio. (a) Binding of wildtype WW1 domain alone (blue) and in the context of mutant WW1-WW2Y tandem module (red). (b) Binding of wildtype WW2 domain alone (blue) and in the context of mutant WW1Y-WW2 tandem module (red).
