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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: FEBS J. 2014 Nov 4;281(24):5532–5551. doi: 10.1111/febs.13095

Figure 9.

Figure 9

Superimposition of simulated structures as derived from MD analysis conducted on the structural model of WW1-WW2 tandem module of YAP2 alone (unliganded) and in complex with LATS1 peptide containing the PPXY motif (liganded). Note that the superimposed structures for the unliganded (a) and liganded (b) WW1-WW2 tandem module were obtained at 100-ns time intervals over the 2000–3000ns time regime in the corresponding MD trajectory. All ten structures were superimposed with respect to the backbone atoms (N, Cα and C) of the core regions of WW1 domain (residues 177–198) and WW2 domain (residues 236–257). In each case, the constituent WW1 (residues 177–198) and WW2 (residues 236–257) domains are respectively colored red and green, while the N-terminal loop (residues 171–176), interdomain linker (residues 199–235) and C-terminal loop (residues 258–264) are respectively shown in blue, gray and magenta. In (b), the LATS1 peptide is not shown for clarity.