Table III.

Factors associated with risk of relapse among minimal residual disease–negative patients in multivariate analysis

Cohort	Prognostic subgroup	HR	95% CI	P
Induction I	t(6;11)/t(10;11)	5.55	2.18–14.17	<0.001
	AMKL without t(1;22)	5.56	1.83–16.89	0.002
	CBF-rearrangement	0.18	0.06–0.59	0.004
	Age ≥ 10 years	6.34	2.64–15.23	<0.001
	High-dose Ara-C arm	0.49	0.21–1.13	0.095
Induction II	t(6;11)/t(10;11)	3.82	1.72–8.48	0.001
	AMKL without t(1;22)	4	1.46–10.99	0.007
	CBF-rearrangement	0.13	0.04–0.39	<0.001
	Age ≥ 10 years	3.26	1.46–7.29	0.004
	Race (Black)	2.25	1–5.03	0.049
	Race (Other)	0.49	0.17–1.4	0.18
	High-dose Ara-C arm	0.64	0.33–1.27	0.21

HR, hazard ratio; CI, confidence interval; AMKL, acute megakaryoblastic leukaemia; CBF, core-binding factor group of genes; Ara-C, cytarabine.