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Schematic representation of funnel-shaped folding landscapes. Example of (a) a smooth folding landscape expected for a two-state folding mechanism where only the native and unfolded states are stably populated and (b) a rugged landscape wherein the polypeptide chain populates one or more intermediate structures which represent local energy minima. Reprinted from [31] by permission from Macmillan Publishers Ltd: Nat. Struct. Mol. Biol. © 2009.
