Table 3.

Most significant canonical pathways enriched with genes associated with interleukin-6 levels

Canonoical pathway	P value	FDR	Ratio+	Genes that were associated with interleukin-6 levels
JAK/Stat Signaling	1.9×10−6	4.7×10−4	13/70 (0.186)	FOS, BCL2L1, SOCS3, RAF1, SOCS1, STAT6, AKT1, JAK1, RRAS, CISH, CDKN1A, TYK2, STAT1
IL-10 Signaling	2.2×10−6	4.7×10−4	13/72 (0.181)	IL1R2, CCR1, FOS, IKBKB, SOCS3, JAK1, IL1RN, BLVRA, TYK2, BLVRB, IL1B, MAP2K3, IL1RAP
Pancreatic Adenocarcinoma Signaling	4.7×10−6	5.6×10−4	16/116 (0.138)	RAF1, E2F4, JAK1, PLD3, PA2G4, TFDP1, TYK2, TGFBR2, BCL2L1, AKT1, CDKN1A, PTGS2, CDKN1B, STAT1, NOTCH1, E2F2
Glucocorticoid Receptor Signaling	5.4×10−6	5.6×10−4	27/280 (0.0964)	TAF12, IL8, RAF1, JAK1, RRAS, SGK1, CDK7, TBP, PBX1, POLR2B, FCGR1A, EP300, TGFBR2, IL1R2, FOS, BCL2L1, IKBKB, AKT1, IL1RN, GTF2E1, CDKN1A, PRKAG2, IL1B, PTGS2, FKBP5, STAT1, PPP3CA
Heme Biosynthesis II	2.0×10−5	1.7×10−3	5/10 (0.5)	UROD, UROS, FECH, ALAS2, HMBS
IGF-1 Signaling	2.7×10−5	1.9×10−3	14/102 (0.137)	FOS, SOCS3, RAF1, SOCS1, NOV, AKT1, JAK1, RRAS, IGF1R, PRKAG2, PDPK1, IRS2, PRKCZ, PRKAR1A
NRF2-mediated Oxidative Stress Response	3.2×10−5	1.9×10−3	20/190 (0.105)	RAF1, UBB, SOD1, RRAS, DNAJA4, HERPUD1, DNAJB2, GSTO1, PRKCZ, EP300, FOS, AKT1, MGST2, MAP2K3, CDC34, FKBP5, DNAJB5, MGST3, EPHX1, GSTK1
Interferon Signaling	4.2×10−5	2.2×10−3	8/34 (0.235)	IFIT3, SOCS1, OAS1, JAK1, TYK2, IFITM1, IFNGR1, STAT1
IL-6 Signaling	5.4×10−5	2.4×10−3	15/122 (0.123)	IL1R2, IKBKB, FOS, SOCS3, RAF1, SOCS1, IL8, AKT1, TNFAIP6, IL1RN, RRAS, IL6R, IL1B, MAP2K3, IL1RAP
NF-κB Signaling	5.8×10−5	2.4×10−3	19/180 (0.106)	RAF1, RRAS, RELB, IGF2R, PRKCZ, EP300, TGFBR2, IL1R2, IKBKB, TNIP1, AKT1, ARAF, TLR5, IL1RN, PELI1, IGF1R, IL1B, CASP8, TNFSF13B
Glioma Signaling	9.1×10−5	3.5×10−3	13/107 (0.121)	RAF1, E2F4, AKT1, PA2G4, CAMK1D, TFDP1, RRAS, CDKN1A, IGF1R, IGF2R, E2F2, PRKCZ, CAMK2G

⁺Ratio is the number of genes that were associated with interleukin-6 levels comparing to the total number of genes in the pathway