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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Curr Opin Genet Dev. 2014 Aug 28;0:10–15. doi: 10.1016/j.gde.2014.08.002

Table 1.

Comparison of naïve and primed pluripotent states

Naïve Primed References
Origin ICM of blastocyst Post-implantation epiblast [1–4,6,7]
Colony Morphology Dome Flat [1–4,6,7]
Single-cell Mortality Low High [1–4,6,7]
XX Chromosomes Dual Activation Single Activation [1–4]
GermlineTransmission High Low [1–4,6,7]
Culture Conditions LIF+BMP4, 2i Activin+bFGF, CHIR+IWR1 [3,4,18–20•]