Table 3. Relationship between renal parameters and primary outcome.

	Unadjusted Analysis			Adjusted Analysis*
Primary Composite	HR†	95% CI	P	HR†	95% CI	P
Baseline SCr	1.06	1.02 – 1.10	0.002	1.04	0.99 – 1.09	0.091
Baseline eGFR	1.20	1.11 – 1.30	< 0.001	1.11	1.02 – 1.21	0.017
Follow-Up SCr	1.05	1.02 – 1.08	0.002	1.05	1.00 – 1.10	0.040
Follow-Up eGFR	1.24	1.15 – 1.33	< 0.001	1.16	1.07 – 1.26	< 0.001
Stable SCr	ref.
≥ 0.3 mg/dL ↓SCr‡	2.02	1.20 – 3.40	0.008	1.11	0.64 – 1.93	0.713
≥ 0.3 mg/dL ↑SCr‡	2.21	1.36 – 3.57	0.001	1.27	0.76 – 2.13	0.368
Stable eGFR	ref.
≥ 25% ↑eGFR‡	1.32	0.81 – 2.15	0.269	0.88	0.53 – 1.47	0.624
≥ 25% ↓eGFR‡	1.71	1.04 – 2.81	0.035	0.92	0.53 – 1.58	0.759
Death	HR	95% CI	P	HR	95% CI	P
Baseline SCr	1.03	0.95 - 1.13	0.424	0.96	0.85 - 1.07	0.433
Baseline eGFR	1.21	1.05 - 1.39	0.009	1.05	0.90 - 1.23	0.514
Follow-Up SCr	1.05	1.00 – 1.11	0.052	1.03	0.94 - 1.14	0.477
Follow-Up eGFR	1.33	1.17 - 1.52	< 0.001	1.23	1.04 - 1.44	0.014
Stable SCr	ref.
≥ 0.3 mg/dL ↓SCr‡	1.92	0.72 - 5.14	0.192	0.81	0.28 - 2.31	0.689
≥ 0.3 mg/dL ↑SCr‡	3.1	1.41 - 6.82	0.005	1.48	0.61 - 3.57	0.387
Stable eGFR	ref.
≥ 25% ↑eGFR‡	1.03	0.39 - 2.73	0.956	0.53	0.19 - 1.52	0.239
≥ 25% ↓eGFR‡	2.26	1.00 – 5.10	0.050	1.03	0.42 - 2.55	0.941

^*Cox proportional hazards model controlling for the following baseline characteristics: age, sex, race, ejection fraction, NYHA class, ischemic etiology, systolic blood pressure, long acting nitrate, hypertension, MLHFQ, diabetes, and loop diuretic.

^†Hazard ratio (HR) calculated per 0.3 mg/dL increments in serum creatinine (SCr) and per 10 mL/min decrements in eGFR.

^‡Improved renal function, defined as a decrease in SCr ≥ 0.3 mg/dL; and an increase in eGFR ≥ 25%.

Worsening renal function, defined as an increase in SCr ≥ 0.3 mg/dL; and a decrease in eGFR ≥ 25%.