Figure 1. Representative structure of α_vβ₃ targeted HPMA copolymer-drug conjugates.

Random copolymers are comprised of four functional monomers: 1) HPMA, which makes up the primary backbone and increases hydrophilicity and aqueous solubility, 2) MA-GFLG-X, where X is either aminohexylgeldanamycin or docetaxel bound to the lysosomally degradable drug linker GFLG via an amide or ester linkage respectively, 3) MA-Tyr-CONH₂, a modified tyrosine to facilitate radiolabeling in future studies, and 4) MA-GG-cRGDfK, which contains the cyclic peptide RGDfK which binds to α_vβ₃ integrins expressed on the surface of ovarian tumor cells and neovasculature.