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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Macromol Biosci. 2014 Sep 4;14(12):1735–1747. doi: 10.1002/mabi.201400360

Figure 3. Competitive binding assay of HPMA copolymer conjugates to cell surface αvβ3 integrins of A2780 human ovarian cancer cells.

Figure 3

All αvβ3 targeted conjugates demonstrated the ability to bind αvβ3 integrins and all non-targeted conjugates showed no evidence of competitive binding. The relative binding affinity of RGDfK was decreased following conjugation to HPMA copolymers, with drug containing (AHGDM and DOC) copolymers showing a greater reduction in binding affinity as compared to control HPMA copolymers (no drug). Data expressed as mean ± SD of three independent experiments, with 3 samples per experiment.