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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Macromol Biosci. 2014 Sep 4;14(12):1735–1747. doi: 10.1002/mabi.201400360

Figure 4. In vitro growth inhibition IC50 values of HPMA copolymer conjugates.

Figure 4

The ability of HPMA copolymer conjugates to inhibit the growth of A2780 and OVCAR-3 human ovarian cancer cells was evaluated in vitro. DOC conjugates exhibited high potency with IC50 values ranging from 1–4 nM, whereas AHGDM conjugates exhibited moderate potency with IC50 values ranging from 3–7 µM. Free RGDfK peptide and control HPMA copolymer-RGDfK demonstrated some potency with IC50 values of 4–7 µM and 16–24 µM respectively. Data expressed as mean ± SD of three independent experiments, with 3 samples per experiment.