Figure 2. Systematic transcriptome analysis shows that genes upregulated in the adrenal glands of gonadectomized mice are more likely to be highly expressed in ovary or testis than in other tissues.

Genes that were differentially expressed in microarray of whole adrenal glands from gonadectomized vs. intact female DBA/2J mice were subjected to enrichment analysis using Fisher’s exact test. Genes defined as “specific” for ovary, testis, adrenal or brain, based on analysis of pooled GEO microarray data (Chen et al., 2013), are shown as yellow circles. Genes that were upregulated in adrenal glands from gonadectomized mice are shown as red circles (↑ GDX). Genes that were downregulated in adrenal glands from gonadectomized mice are shown as blue circles (↓ GDX). Enrichment analysis demonstrated that genes upregulated in the adrenal glands of gonadectomized mice were more likely to be highly expressed in ovary (A) or testis (B) than in brain (D). Genes that were downregulated in the adrenal glands of gonadectomized mice were more likely to be highly expressed in the normal adrenal tissue (C) than in brain (E).