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Annexin-A8 protein expression increases as tumor grade increases in pancreatic cancer. A, Immunohistochemical staining of A-A8 predominantly presented in the cytoplasm. The stroma surrounding the low-grade and high-grade adenocarcinoma demonstrate expression for A-A8 in fibroblasts or stellate cells and also some lymphocytes. B, Differences in annexin-A8 protein staining by immunohistochemical score between low-grade and high-grade pancreatic cancer.
