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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: FEBS J. 2014 Oct 30;281(24):5567–5580. doi: 10.1111/febs.13098

Figure 3. Effect of Epi on oxidative stress regulatory systems.

Figure 3

Protein levels of sirtuin-3 (SIRT3), thioredoxine (TRX), glutathione peroxidase (GPx), mitochondrial superoxide dismutase (SOD2) and catalase were analyzed by Western blot. Significant decreases were observed in Ctrl δ-KO mice as compared vs. Ctrl WT mice (*P<0.05). In the Epi δ-KO, treatment either partially restored or fully recovered their levels. (#P<0.05 Epi δ-KO vs Ctrl δ-KO). In Epi WT animals there was a significant increase in the levels of TRX and SOD2 in SkM, while in heart there was an increase in SIRT3, TRX, and SOD2 vs. Ctrl WT (‡P<0.05). The bargraphs report on densitometric analysis as: protein/GAPDH for each group. n=5 animals/group.