Figure 5. Effects of Epi on mitochondrial related proteins.
Protein levels for the mitochondrial related proteins SIRT1, PGC1α, TFAM, porin, mitofilin and CV were analyzed by Westerns. Ctrl δ-KO mice evidenced decreased levels of the proteins as compared vs. Ctrl WT mice (*P<0.05). In the Epi δ-KO, treatment either partially restored or fully recovered their levels (#P<0.05 Epi δ-KO vs Ctrl δ-KO). In Epi WT group there was a significant increase in the levels of PGC1α, TFAM, porin, mitofilin and CV in SkM and heart vs. Ctrl WT (‡P<0.05). The bargraphs report on densitometric analysis as: protein/GAPDH for each group. n=5 animals/group.