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Citrate synthase activity was quantified in quadriceps (A) and heart (B). A decrease in enzymatic activity was observed in Ctrl δ-KO mice as compared vs. Ctrl WT mice (*P<0.05). In the Epi δ-KO group, treatment fully restored enzyme activity (#P<0.05 Epi δ-KO vs Ctrl δ-KO). Epi WT mice significantly increased enzyme activities vs. Ctrl WT (‡P<0.05). n=5 animals/group.
