Table 2.
Parameter |
V0 [Log10 IU/mL] |
εmax |
k [d−1] |
δ [d−1] |
||||
---|---|---|---|---|---|---|---|---|
Severity of liver disease |
Non- cirrhotic |
Compensated cirrhosis |
Decompensated cirrhosis # |
Non- cirrhotic |
Compensated cirrhosis |
Decompensated cirrhosis |
||
Estimate (Standard error S.E) | 6.4 (0.3) | 6.3 (0.6) | 4.7 (0.8) | 0.861 (0.047) | 0.685 (0.064) | 0.59 (0.098) | 2.12 (0.18) | 0.62 (0.05) |
- | p=0.68 | p<0.0001 | - | p=0.032 | p=0.03 | |||
Between-subject variability [%] (SE) | 133 (20) | 16.6 (3.7) | 13.9 (9.7) | 31.8 (6.4) |
V0, HCV baseline viral load; εmax, maximal SIL efficacy; k, rate constant describing the time to reach maximal drug effectiveness, and δ the infected cell loss rate. Individual parameter estimates are shown in Table S2. p, p-value for the difference from the non-cirrhotic group (Wald test).