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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2014 Sep 28;263:277–284. doi: 10.1016/j.expneurol.2014.09.015

Fig. 5.

Fig. 5

Nicotine prevents the 6-OHDA-induced loss in striatal nAChR-evoked dopamine release. Rats were administered vehicle or nicotine via minipump and lesioned using 6-OHDA. Synaptosomal nicotine-evoked 3H-dopamine release was determined in response to 1 and 10 µM nicotine in intact and lesioned striatum. Release was done in the absence (total nAChR-mediated release) and presence of 50 nM α-CtxMII (α4β2* nAChR-mediated release) with the difference in release defined as α6β2* nAChR-mediated release. Values are the mean ± SEM of 22–25 rats per group. Significance of difference from the vehicle-treated intact side, ***p < 0.001; from vehicle-treated lesioned side, #p < 0.05, ###p < 0.001 using two-way ANOVA followed by a Bonferroni post hoc test.