Table 8.
Analysis of the differential gene pathways
| Pathway | Number of entities | Matched with technology | Matched with entity list | P value |
|---|---|---|---|---|
| P450 Hydroxylations | 19 | 4 | 2 | 0.002811053 |
| HIF-1-alpha transcription factor network | 88 | 73 | 6 | 0.002937696 |
| Mechanism of acetaminophen activity and toxicity | 12 | 5 | 2 | 0.004168975 |
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | 111 | 86 | 6 | 0.006581206 |
| Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (B2AR) pathway | 14 | 3 | 1 | 0.006656855 |
| De novo synthesis of IMP | 32 | 4 | 1 | 0.011070482 |
| Cytochrome p450 | 54 | 9 | 2 | 0.01444615 |
| Phase 1 functionalization | 87 | 9 | 2 | 0.01444615 |
| il12 and stat4 dependent signaling pathway in th1 development | 13 | 10 | 2 | 0.015267268 |
| alpha6beta4integrin | 53 | 50 | 4 | 0.01597487 |
| IL4-mediated signaling events | 84 | 52 | 4 | 0.018223463 |
| Purine metabolism | 100 | 9 | 1 | 0.022020191 |
| Xenobiotics | 60 | 15 | 2 | 0.0333969 |
| Stathmin and breast cancer resistance to antimicrotubule agents | 18 | 2 | 1 | 0.03385132 |
| Negative regulation of the PI3 K/AKT network | 12 | 2 | 1 | 0.03385132 |
| TCR | 140 | 125 | 6 | 0.035289083 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 7 | 2 | 1 | 0.038461793 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 7 | 2 | 1 | 0.038461793 |
| FOXA1 transcription factor network | 53 | 40 | 3 | 0.04229567 |
| Nucleotide metabolism | 198 | 22 | 1 | 0.049933493 |