Figure 2.
Postconditioning (Day 5) in adolescent male offspring. Following three days of place conditioning with either saline or morphine (1 or 5 mg/kg), VEH-F1 and WIN-F1 adolescent males were tested for conditioned place preference (CPP) and locomotor activity for 15 min. Panel (a) data are differences in the time spent in seconds (mean± SEM) in the chamber paired with drug from the unpaired chamber. **p< 0.01 vs. WIN-F1 saline-treated group. Panel (b) locomotor activity (mean number of beam breaks ± SEM) during CPP testing. *p< 0.05 as compared with 5 mg/kg morphine groups, collapsed across maternal drug history. For both panels sample sizes are as follows: 7–9 animals per dose VEH-F1 and 10–12 animals per dose WIN-F1 animals.
