Supplemental Table 3.
Baseline characteristics of the participants according to the number of baseline components of MetS
| Characteristics | Number of baseline MetS components |
p for trend1 | ||
|---|---|---|---|---|
| Zero (n=5234) | One (n=5576) | Two (n=4096) | ||
| Total person-years | 19 880.2 | 19 883.3 | 12 702.6 | |
| Average person-years | 3.80±1.39 | 3.57±1.48 | 3.10±1.53 | |
| Uric acid | 5.8 (0.02) | 6.1 (0.02) | 6.3 (0.02) | <0.001 |
| Age (y) | 44.5 (0.02) | 44.6 (0.02) | 44.6 (0.02) | 0.001 |
| Body mass index (kg/m2) | 22.8 (0.03) | 24.0 (0.03) | 25.2 (0.04) | <0.001 |
| Waist circumference (cm) | 79.6 (0.08) | 83.0 (0.09) | 86.4 (0.11) | <0.001 |
| Systolic BP (mmHg) | 105.9 (0.13) | 112.0 (0.17) | 118.0 (0.23) | <0.001 |
| Diastolic BP (mmHg) | 73.0 (0.09) | 77.4 (0.11) | 81.3 (0.15) | <0.001 |
| Total cholesterol (mg/dL) | 186.7 (0.40) | 195.0 (0.42) | 200.1 (0.50) | <0.001 |
| Triglyceride (mg/dL) | 93.0 (0.38) | 131.6 (0.84) | 172.1 (1.33) | <0.001 |
| HDL-cholesterol (mg/dL) | 54.8 (0.14) | 51.4 (0.14) | 48.7 (0.15) | <0.001 |
| LDL-cholesterol (mg/dL) | 109.8 (0.36) | 115.4 (0.36) | 117.4 (0.43) | <0.001 |
| Fasting serum glucose (mg/dL) | 91.1 (0.08) | 97.0 (0.18) | 101.8 (0.28) | <0.001 |
| HOMA-IR | 1.69 (0.008) | 2.06 (0.01) | 2.44 (0.02) | <0.001 |
| Insulin (μU/dL) | 7.5 (0.04) | 8.6 (0.04) | 9.8 (0.06) | <0.001 |
| Serum creatinine (mg/dL) | 1.12 (0.002) | 1.13 (0.003) | 1.14 (0.002) | <0.001 |
| eGFR (mL/min per 1.73 m2) | 80.3 (0.12) | 79.5 (0.12) | 78.5 (0.14) | <0.001 |
| Aspartate aminotransferase (U/L) | 24.5 (0.33) | 24.9 (0.12) | 26.8 (0.17) | <0.001 |
| Alanine aminotransferase (U/L) | 25.0 (0.44) | 28.5 (0.23) | 33.6 (0.32) | <0.001 |
| γ-glutamyltransferase (U/L) | 29.1 (0.38) | 38.8 (0.47) | 48.9 (0.71) | <0.001 |
| hsCRP (mg/L) | 0.11 (0.008) | 0.13 (0.007) | 0.14 (0.006) | 0.003 |
| Current smoker (%) | 36.8 (0.7) | 39.9 (0.7) | 42.7 (0.8) | <0.001 |
| Alcohol intake (%) | 10.1 (0.4) | 13.7 (0.5) | 16.2 (0.6) | <0.001 |
| Regular exercise (%) | 20.8 (0.6) | 19.4 (0.5) | 17.8 (0.6) | <0.001 |
| Diabetes mellitus (%) | 0.3 (0.08) | 2.6 (0.2) | 6.1 (0.4) | <0.001 |
| Hypertension (%) | 1.8 (0.2) | 14.2 (0.5) | 29.2 (0.7) | <0.001 |
| Development of MetS (%) | 3.6 (0.3) | 14.2 (0.5) | 35.2 (0.8) | <0.001 |
Values are presented as means (standard error), or percentages (standard error).
MetS, metabolic syndrome; BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein.
1
p-value was tested by multiple linear regression models for continuous variables and multiple logistic regression models for categorical variables after adjusting for 5 year-age group.