Table 2.

Odds ratios for risk of depression for demographic and disease factors

Variable	Groups	Positive depression screen^, N(%)	p	Unadjusted OR	p
Education	Postgraduate degree	70/ 520 (13.5)†	<0.001	1.0	-
	Bachelor degree	137 808/(17.0)†		1.31 (0.96–1.79)	0.087
	Vocational training	84/ 355 (23.7)*		1.99 (1.40–2.83)	<0.001
	No school/primary/secondary	138/ 533 (25.9)*		2.25 (1.64–3.09)	<0.001
Marital status	Married/partnered/cohabitating	285/ 1642 (17.4)†	0.001	1.0	-
	Single	73/ 304 (24.0)*		1.51 (1.12–2.02)	0.006
	Separated/divorced/widow(er)	64/ 248 (25.8)*		1.66 (1.21–2.26)	0.002
Employment	Work full time	119/ 729 (16.3)†	<0.001	1.0	-
	Work part time	66/ 473 (14.0)†		0.83 (0.60–1.15)	0.266
	Stay at home parent/carer	26/ 172 (15.1)†		0.91 (0.58–1.45)	0.698
	Unemployed	46/167 (27.5)*		1.95 (1.32–2.89)	0.001
	Retired due to disability	150/ 508 (29.5)*		2.15 (1.63–2.82)	<0.001
	Retired due to age	6/ 70 (8.6) †		0.48 (0.20–1.14)	0.095
	Other (includes student)	15/ 101 (14.9)†		0.89 (0.50–1.60)	0.706
Disability	Mild	169/ 1215 (13.9)†	<0.001	1.0	-
	Moderate	199/ 767 (25.9)*		2.17 (1.73–2.73)	<0.001
	Severe	59/ 236 (25.0)*		2.06 (1.74–2.89)	<0.001
Type of MS	Relapsing-remitting	252/ 1359 (18.5)†	0.015	1.0	-
	Benign	10/ 95 (10.5)		0.52 (0.27–1.01)	0.053
	Primary progressive	35/ 160 (21.9)		1.23 (0.83–1.83)	0.309
	Secondary progressive	56/ 256 (21.9)		1.23 (0.89–1.71)	0.214
	Progressive relapsing	16/ 46 (34.8)*		2.34 (1.26–4.36)	0.007
	Unsure/other	58/ 301 (19.3)		1.05 (0.76–1.44)	0.770
Number of comorbidities	None	53/ 737 (7.2)†	<0.001	1.0	-
	One	86/ 583 (14.8)†		2.23 (1.56–3.21)	<0.001
	Two	110/ 452 (24.3)*		4.15 (2.92–5.91)	<0.001
	Three	103/ 259 (39.8)*		8.52 (5.86–12.39)	<0.001
	Four	40/ 110 (36.4)*		7.38 (4.57–11.90)	<0.001
	Five or more	36/ 80 (45.0)*		10.56 (6.27–17.79)	<0.001
Clinically significant fatigue	No	29/ 732 (4.0)†	<0.001	1.0	-
	Yes	379/ 1393 (27.2)*		9.06 (6.14–13.38)	<0.001

*denotes overrepresentation and † denotes underrepresentation ^ PHQ-2 score ≥3. Bold denotes statistically significant.