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. 2014 Dec 11;8:985. doi: 10.3389/fnhum.2014.00985

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Copyright © 2014 Leckie, Oberlin, Voss, Prakash, Szabo-Reed, Chaddock-Heyman, Phillips, Gothe, Mailey, Vieira-Potter, Martin, Pence, Lin, Parasuraman, Greenwood, Fryxell, Woods, McAuley, Kramer and Erickson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Moderated mediation model. (A) Moderation Model: Effect of exercise group on BDNF serum levels as a function of age. (B) Mediation Model: Effect of exercise group on Task-Switch accuracy cost as a function of BDNF serum levels. Note: Solid arrow indicates direct pathway; Dashed arrow indicates indirect pathway. (C) Moderated Mediation Model: Mediating effect of BDNF serum levels on the effect of exercise group on Task-Switch accuracy cost as a function on age. Note: Solid arrow indicates moderation; Dashed arrow indicates mediation.