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. 2014 Dec 11;8:985. doi: 10.3389/fnhum.2014.00985

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Copyright © 2014 Leckie, Oberlin, Voss, Prakash, Szabo-Reed, Chaddock-Heyman, Phillips, Gothe, Mailey, Vieira-Potter, Martin, Pence, Lin, Parasuraman, Greenwood, Fryxell, Woods, McAuley, Kramer and Erickson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Moderating effect of age (stratified). Note: Effects of exercise on serum BDNF as a function of age. Age stratified using a median split. (A) Serum BDNF decreases following the intervention in the control group among adults >65 years. (B) Serum BDNF increases following 1 year of walking exercise, specifically for adults aged >65 years.