Figure 1.

Methods to assess resting-state brain function. Resting-state fMRI time series allow the description of functional networks at multiple levels. Local markers of functional integrity can be derived from the amplitude of low-frequency fluctuations. Seed-based analysis of connectivity relies on cross-correlations between time-series of seed and target regions. Systematic seeding across multiple regions allows for the generation of connectivity matrices and equivalent connectivity graphs; these can, in turn, be analyzed using graph-theory to address large-scale network topology.