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. 2014 Dec 5;9:165. doi: 10.1186/s13023-014-0165-x

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© Ng et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cyclin E2 expression was associated with high proliferation rate and poor outcome in TNKLPD. Significantly higher cyclin E2 expression was present in M-group compared to P-group patients (A, median expression of 42% compared with 8%, p = 0.0005). Patients with high tumor cyclin E2 expression of 15% or greater had statistically significant shorter survival compared with those with low cyclin E2 expression less than 15% (B, p = 0.0002). High cyclin E2 expression is highly correlated with high Ki-67 proliferation rate (C, spearman r = 0.73, p = 0.0006).