Figure 4. Successful encoding activity in pyramidal layers of CA1 predicts later memory and is correlated with activation in deep EC regions.

(a) High confidence recognition and recollection estimates in the subsequent memory test were correlated with successful encoding activity strength in the pyramidal (‘output’) layers of CA1 across subjects (N=20). Activation strength is defined as the mean contrast estimate (weighted betas for DM contrast) of all voxels in our anatomically defined ROI (pyramidal CA1). Betas were extracted from the individual unnormalized and unsmoothed functional data using subject-specific anatomical masks. (b) Functional connectivity analyses (PPI) yielded significant functional coupling of deep EC regions (seed) with pyramidal layers of CA1 during successful encoding (P_{voxel level}<0.005: k=26 voxels, alpha<0.05, N=19). Group results are depicted on the T1-group template after normalization with ANTS (left). In addition, results are illustrated for one sample subject on the individual MPRAGE (right).