Table 3.
Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated HEI-2005 and ovarian cancer from 1986 through 2010 among women in the NHS
| HEI-2005 | |||||||
|---|---|---|---|---|---|---|---|
| N cases | ≤56 | >56-63 | >63-68 | >68-74 | >74 | P trend | |
| N cases | 127 | 117 | 129 | 162 | 161 | ||
| Person-years | 294,749 | 294,665 | 294,337 | 293,738 | 292,082 | ||
| Age-adjusted | 696 | 1.00 (Ref) | 0.82 (0.63,1.05) | 0.85 (0.66,1.09) | 0.99 (0.78,1.26) | 0.92 (0.72,1.17) | 0.98 |
| Multivariable* | 696 | 1.00 (Ref) | 0.79 (0.61,1.03) | 0.82 (0.63,1.06) | 0.93 (0.72,1.20) | 0.85 (0.65,1.12) | 0.57 |
| Invasive* | 592 | 1.00 (Ref) | 0.80 (0.60,1.05) | 0.80 (0.60,1.05) | 0.91 (0.69,1.20) | 0.86 (0.64,1.15) | 0.60 |
| Borderline* | 57 | 1.00 (Ref) | 1.00 (0.45,2.24) | 1.11 (0.50,2.43) | 0.97 (0.42,2.20) | 0.54 (0.20,1.43) | 0.31 |
| Serous/poorly differentiated* | 435 | 1.00 (Ref) | 0.81 (0.59,1.13) | 0.91 (0.66,1.25) | 0.91 (0.66,1.26) | 0.90 (0.64,1.27) | 0.79 |
| Non-serous* | 148 | 1.00 (Ref) | 0.77 (0.46,1.31) | 0.70 (0.41,1.21) | 1.03 (0.62,1.69) | 0.83 (0.49,1.43) | 0.81 |
| Rapidly fatal* | 247 | 1.00 (Ref) | 0.76 (0.51,1.14) | 0.62 (0.40,0.94) | 0.67 (0.44,1.02) | 0.75 (0.50,1.13) | 0.15 |
| Less aggressive* | 274 | 1.00 (Ref) | 0.79 (0.52,1.18) | 0.89 (0.60,1.32) | 1.08 (0.73,1.59) | 0.85 (0.556,1.29) | 0.89 |
*Adjustment factors are listed in the Statistical Analyses section.
P values for heterogeneity by tumor subtype were 0.42, 0.95, and 0.32 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive tumors, respectively.