Table 3.

Sensitivity analysis of the changes of the proportion of fibrin and necrotic tissue from day 0 to day 14

	PA-based hydrogel n = 34	Amorphous gel n = 40	P-value
Mean of means of three blinded experts
Absolute change in pp* ± SD	39.0 ± 27.3	17.9 ± 20.4	0.002*
Relative change in% ± SD	46.7 ± 32.3	24.8 ± 32.6	0.011*
Relative change in% [CI]	46.3 [34.9; 57.7]	25.1 [14.6; 35.6]	0.009**
Mean of medians of three blinded experts
Absolute change in pp* ± SD	37.6 ± 29.9	16.8 ± 23.0	0.004*
Relative change in% ± SD	43.4 ± 36,7	21.9 ± 39.4	0.018*
Relative change in% [CI]	41.9 [28.6; 55.1]	23.2 [11.0; 35.4]	0.046**
Mean of investigators
Absolute change in pp ± SD	45.0 ± 28.5	28.5 ± 25.16	0.016*
Relative change in% ± SD	53.1 ± 32.5	34.2 ± 29.6	0.015*

^*Wilcoxon-Mann–Whitney test (two-sided), t-approximation, because non-Gaussian variable

^**Covariate is baseline% of fibrin and necrotic tissue covering ulcer area.

CI, confidence interval; pp, percentage points; SD, standard deviation.