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. 2014 Nov 21;9(11):e113787. doi: 10.1371/journal.pone.0113787

Figure 3. Effects of intrahippocampal injection of CGP 35348 on BSR performance and the associated fPSP changes.

Figure 3

(A) The upper panel shows representative fPSPs (averaged 15 times) evoked at the CA3-CA1 synapse before injection (black solid line), in the presence of vehicle (gray dotted line) or following CGP injection (gray solid line). The bottom histograms illustrate the averaged fPSP amplitudes corresponding to glutamate- (GLU) and GABA-related components (GABAA and GABAB). Comparisons were made vs. vehicle injection (horizontal dashed line). (B) CGP effects on animals' BSR determined as (number of reinforcements obtained)/(maximum number of available reinforcements) x 100. Illustrated data range from two days before to two days after (white circles) an intrahippocampal single injection (black circle) of CGP. (C) Quantitative effects of CGP injection on fEPSP amplitude. Two sessions prior to (−2, −1) and two sessions after (1, 2) the injection day (black dot) are illustrated. The statistical comparisons are represented vs. BL values (dashed line in 100%). (D) As in C, same quantitative representation of effects induced by CGP injection but for fIPSP (GABAB) amplitude. The statistical comparisons are indicated vs. BL values (dashed line in 100%) (*) P<0.05; (**) P<0.01; (***) P<0.001. Code bars at the top in each section are defined in Figure 1.