Table 2.

Univariate Cox regression analysis of the clinical and biochemical parameters associated with the development of an event

Parameters	Event		P-value (χ² test)	HR	95% CI for HR		Cox Reg.
	Absent	Present			Lower	Upper
Gender
Female	16	7	0.08	Ref.	Ref.	Ref.	0.09
Male	25	27		2.07	0.90	4.77
Age
<40 years	28	13	<0.01	Ref.	Ref.	Ref.	0.04
≥40 years	13	21		2.10	1.05	4.20
Region of origin
E.E.	16	5	0.02	Ref.	Ref.	Ref.	0.02
E.M.	11	19		3.76	1.40	10.12	<0.01
Others	14	10		2.1	0.72	6.16	0.18
Cirrhosis
Absent	28	10	<0.01	Ref.	Ref.	Ref.	0.01
Present	13	24		2.63	1.26	5.51
Bilirubin
<ULN	29	18	0.09	Ref.	Ref.	Ref.	0.04
≥ULN	6	10		2.21	1.02	4.83
Albumin
>35 mg/dL	30	13	<0.01	Ref.	Ref.	Ref.	<0.01
≤35 mg/dL	2	10		3.10	1.36	7.09
INR
≤1.2	32	11	<0.01	Ref.	Ref.	Ref.	<0.01
>1.2	4	20		4.56	2.17	9.56
Thrombocytes
≥100 000/mL	35	8	<0.01	Ref.	Ref.	Ref.	<0.01
50–100 000/mL	4	16		6.65	2.81	15.72	<0.01
<50 000/mL	1	6		11.63	3.87	34.94	<0.01

HR, hazard ratio; CI, confidence interval; E.E, Eastern Europe (Russia, Kazakhstan, Poland, Tadzhikistan, Ukraine and Uzbekistan); E.M, Eastern Mediterranean (Turkey, Syria and Iran); Ref, reference value (HR = 1).