Figure 2. Canonical pathways identified by IPA associated with organismal growth and development (A, B), and cellular growth, proliferation and development (C, D) in the retina of uninjected (A, C) and nanoceria injected (B, D) Vldlr−/− mouse.

The stack bar chart displays for each canonical pathway the number of genes that are found to be significant. The numerical value at the top of each bar represents the total number of genes/molecules in the canonical pathway. The Benjamini-Hochberg (BH) method was used to adjust the right-tailed Fisher’s Exact t-test p-values, which measure how significant each pathway is. Canonical pathway displays the number of up-regulated (red) and down-regulated (green) genes in each canonical pathway. The yellow line represents the threshold p-value.