Table 1.
List of differentially expressed genes (≥ 1.5 fold) in the retina of Vldlr−/− mice. Data are expressed as fold change of Vldlr−/− mice (n=4) to Wt mice (n=4). *P<0.05
| Gene name | Gene symbol | Vldlr/Wt | |
|---|---|---|---|
| Fold change | p-value | ||
| Up-regulated genes | |||
| Thymic stromal lymphopoietin | Tslp | 7.8 | 0.0851 |
| Fibroblast growth factor 7 | Fgf7 | 7.0 | 0.0356* |
| Fibroblast growth factor 2 | Fgf2 | 6.8 | 0.0233* |
| Leukemia inhibitory factor | Lif | 5.9 | 0.1090 |
| Interferon epsilon 1 | Ifnel | 5.3 | 0.0464* |
| Interleukin 3 | Il3 | 4.2 | 0.2062 |
| Fibroblast growth factor 15 | Fgf15 | 3.5 | 0.0415* |
| Fibroblast growth factor 6 | Fgf6 | 2.8 | 0.1650 |
| Fibroblast growth factor 1 | Fgf1 | 2.7 | 0.0017* |
| Cardiotrophin-like cytokine factor 1 | Clc | 2.3 | 0.3340 |
| Fibroblast growth factor 3 | Fgf3 | 2.3 | 0.0602 |
| Growth hormone | Gh | 2.3 | 0.5731 |
| Fibroblast growth factor 14 | Fgf14 | 2.1 | 0.0016* |
| Colony stimulating factor 1 | Csf1 | 2.1 | 0.0560* |
| Fibroblast growth factor 16 | Fgf16 | 2.1 | 0.4231 |
| Angiopoietin 1 | Angpt1 | 2.0 | 0.1330 |
| Fibroblast growth factor 5 | Fgf5 | 2.0 | 0.0378* |
| Interleukin 23 a | Il23a | 2.0 | 0.1206 |
| Interleukin 6 | Il6 | 2.0 | 0.3177 |
| Ephrin A3 | Efna3 | 1.9 | 0.0283* |
| C-fos induced growth factor | Figf | 1.9 | 0.3595 |
| Fibroblast growth factor 9 | Fgf9 | 1.8 | 0.0402* |
| Fibroblast growth factor 17 | Fgf17 | 1.8 | 0.0763 |
| Interleukin 19 | Il19 | 1.8 | 0.2910 |
| Interferon gamma | Ifng | 1.8 | 0.2202 |
| Neuregulin 3 | Nrg3 | 1.8 | 0.3170 |
| Epidermal growth factor | Egf | 1.7 | 0.1051 |
| Interleukin 7 | Il7 | 1.7 | 0.1061 |
| Interleukin 9 | Il9 | 1.6 | 0.0508* |
| Leptin | Lep | 1.6 | 0.1701 |
| Vascular endothelial growth factor A | Vegfa | 1.6 | 0.1340 |
| Fibroblast growth factor 20 | Fgf20 | 1.6 | 0.3673 |
| Fibroblast growth factor 21 | Fgf21 | 1.6 | 0.1642 |
| Oncostatin M | Osm | 1.5 | 0.1864 |
| Fibroblast growth factor 10 | Fgf10 | 1.5 | 0.1527 |
| Ephrin A1 | Efna1 | 1.5 | 0.0860 |
| Erythropoietin | Epo | 1.5 | 0.0831 |
| Down-regulated genes | |||
| Interleukin 5 | Il5 | −3.4 | 0.2791 |
| Zing finger protein 91 | Zfp91 | −2.0 | 0.0380* |
| Angiopoietin 4 | Angpt4 | −1.8 | 0.4382 |
| Interleukin 11 | Il11 | −1.8 | 0.2920 |
| Interleukin 10 | Il10 | −1.8 | 0.1511 |