Table 3.

Top 5 genetic networks in the retina of the Vldlr−/− mouse (↑ up- and ↓down-regulation)

Network	Genes	Score	Focus genes	Functions
1	↑Fgf1, ↑Fgf3, ↑Fgf6, ↑Fgf7, ↓Fgf8, ↑Fgf9, ↑Fgf10, ↑Fgf11, ↓Fgf12, ↑Fgf13, ↑Fgf14, ↑Fgf16, ↑Fgf17, ↑Fgf18, ↑Fgf20, ↑Fgf21, ↑Fgf22, ↑Fgf23, ↑Figf, ↑Nrg3, ↑Nrg4, ↑Pdgfc, ↑Vegfb	52	23	Cell-to-cell signaling and interactions, tissue development, cardiovascular system development and function
2	↓Ctf1, ↑Efna1, ↑Efna2, ↑Efna3, ↑Efna4, ↑Efna5, ↑Fgf5, ↓Ifnk, ↑Il19, ↑IL24, ↑IL12a, ↑IL12b, ↑IL23a, ↑Ntf3, ↑Tslp, ↓Vegfc	32	16	Cellular assembly and organization, nervous system development and function, gastrointestinal disease
3	↓Il5, ↑Il7, ↓Il10, ↓Il11, ↓Il13, ↑Il15↑Il20, ↑Lif, ↑Osm, ↓Tpo	18	10	Cell-to-cell signaling and interaction, cellular growth and proliferation, hematological system development and function
4	↓Angpt4, ↓Csf3, ↑Efnb1, ↑Efnb3, ↑Epo, ↑Hgf, ↓Il2, ↑I13, ↑Lep	19	9	Cell-to-cell signaling and interaction, cellular growth and proliferation, hematological system development and function
5	↑Angpt1, ↑Angpt2, ↑Csf1, ↑Efnb2, ↑Fgf2, ↑Gas6, ↑Pdgfd, ↑Vegfa	13	8	Cardiovascular system development and function, cellular growth and proliferation, embryonic development