Table 4.

Top 5 genetic networks in the retina of nanoceria injected Vldlr−/− mouse (↑up- and ↓down-regulation)

Network	Genes	Score	Focus genes	Functions
1	↓Fgf1, ↓Fgf3, ↑Fgf6, ↓Fgf7, ↓Fgf8, ↓Fgf9, ↑Fgf10, ↓Fgf11, ↓Fgf12, ↓Fgf13, ↑Fgf14, ↑Fgf16, ↑Fgf17, ↑Fgf18, ↑Fgf20, ↓Fgf21, ↓Fgf22, ↓Fgf23, ↑Figf, ↓Nrg3, ↓Nrg4, ↓Pdgfc, ↓Vegfb	52	23	Cell-to-cell signaling and interactions, tissue development, cardiovascular system development and function
2	↓Efna1, ↓Efna2, ↓Efna3, ↓Efna4, ↓Efna5, ↑Fgf5, ↑Il19, ↑IL24, ↑IL12a, ↓IL12b, ↑IL23a, ↓Ntf3, ↓Tslp, ↓Vegfc	28	14	Cellular assembly and organization, nervous system development and function, gastrointestinal disease
3	↓Ctf1, ↑Epo, ↑Il5, ↓Il7, ↓Il10, ↓Il11, ↑Il13, ↑Il15, ↓Il20, ↓Lif, ↓Osm, ↓Tpo	23	12	Cell death, growth and proliferation, hematological system development and function
4	↓Angpt1, ↓Angpt2, ↓Csf1, ↓Efnb1, ↓Efnb2, ↓Efnb3, ↓Fgf2, ↓Gas6, ↓Nrg1, ↓Pdgfd, ↓Vegfa	20	11	Cardiovascular system development and function, embryonic development, tissue development
5	↓Cls, ↓Fgf13, ↑Ifng, ↓Il9, ↑Il19, ↓IIl20, ↓Zfp91	11	7	Cellular development, growth and proliferation, connective tissue development and function