Table 2. Efficacy of antimalarials on P. falciparum grown in low [Na+] medium.
| Compound | P. falciparum line | EC50 in normal [Na+] medium, nM (±s.e.m.) | EC50 in low [Na+] medium, nM (±s.e.m.) |
|---|---|---|---|
| PA21A050 | Dd2 | 0.5 (±0.01) | 2.7 (±0.3) |
| PA21A085 | Dd2 | 5.7 (±0.3) | 19 (±0.9) |
| PA21A085 | Dd2-21R | 221 (±20) | >5,000 |
| NITD246 | Dd2 | 0.5 (±0.03) | 1.8 (±0.1) |
| NITD246 | Dd2-21R | 0.7 (±0.02) | 3.3 (±0.15) |
| Artemisinin | Dd2 | 11 (±0.4) | 7 (±0.13) |
EC50, effective concentration for 50% growth inhibition.
Growth inhibition assays were carried out for Dd2 and a compound 2-1 resistant line (Dd2-21R) using the indicated pyrazoleamide and a spiroindolone. The assays were carried out either in the normal growth medium or in a low [Na+] medium described in ref. 27.