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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: Cell. 2014 Aug 7;158(4):778–792. doi: 10.1016/j.cell.2014.07.023

Figure 4. Conformational ‘expansion’ of LBD-TMD linker region upon receptor activation.

Figure 4

A–D. Top down views of the D2 (helix E) -M3 linker region of full-length structures in complex with competitive antagonist ZK (A; PDB code 3KG2), in the apo state (B), in complex with partial agonist KA+(R,R)-2b (C) and in complex with partial agonist FW+(R,R)-2b (D). E. Location of marker residue Ser 640 on helix E where Cαs are shown as orange spheres for the distal BD pair and as blue spheres for the short diagonal A/C pair, respectively. F. Plot of AC versus BD distances, measured between Cαs of Ser 640, for the indicated full-length structures, showing the increase in "pulling force" caused by the D2 separation of GluA2 receptor with partial agonists + (R,R)-2b compared to antagonist-bound and apo structures. See also Figure S4.

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