Table 1.
Comparisons of host and viral factors between IL28B TT and TG/GG genotypes
| Factors | TT genotype (154) | TG/GG genotype (61) | P value |
|---|---|---|---|
| Age (years) | 58 ± 11 (154) | 58 ± 12 (61) | 0.679 |
| Gender (male/female) | 88/66 | 31/30 | 0.448 |
| Body weight (kg) | 60.2 ± 11.2 (149) | 58.7 ± 12.5 (60) | 0.318 |
| IFN naïve/experienced | 123/31 | 47/14 | 0.711 |
| PEG-IFN-α2a/-α2b | 23/131 | 11/50 | 0.679 |
| Albumin (g/dL) | 4.1 ± 0.5 (153) | 4.1 ± 0.4 (60) | 0.721 |
| AST (U/L) | 56 ± 37 (154) | 66 ± 49 (61) | 0.332 |
| ALT (U/L) | 70 ± 52 (154) | 77 ± 59 (61) | 0.422 |
| T.Bil (mg/dL) | 0.86 ± 0.33 (150) | 0.84 ± 0.37 (61) | 0.658 |
| ALP (U/L) | 268 ± 93 (154) | 254 ± 87 (61) | 0.509 |
| γ-GTP (U/L) | 46 ± 43 (154) | 78 ± 99 (61) | < 0.001 |
| T.Chol (mg/dL) | 172 ± 39 (151) | 160 ± 29 (58) | 0.013 |
| LDL-C (mg/dL) | 103 ± 28 (132) | 84 ± 27 (57) | < 0.001 |
| FBS (mg/dL) | 101 ± 21 (130) | 108 ± 29 (53) | 0.076 |
| IRI (μU/mL) | 10.9 ± 9.5 (66) | 15.5 ± 20.9 (26) | 0.541 |
| AFP (ng/mL) | 14.4 ± 67.1 (141) | 17.8 ± 26.2 (57) | 0.009 |
| HCV RNA (Log IU/mL) | 6.5 ± 0.5 (154) | 6.4 ± 0.6 (61) | 0.243 |
| WBC (/μL) | 4917 ± 1367 (154) | 4940 ± 1105 (61) | 0.525 |
| Hemoglobin (g/dL) | 13.8 ± 1.3 (154) | 13.7 ± 1.7 (61) | 0.633 |
| Platelets (x104/μL) | 16.5 ± 5.9 (154) | 16.9 ± 4.7 (61) | 0.347 |
| FIB-4 index | 2.82 ± 1.77 (154) | 2.80 ± 1.76 (61) | 0.994 |
| Core 70 amino acid (wild/mutant) | 109/43 | 18/41 | < 0.001 |
| Core 91 amino acid (wild/mutant) | 102/50 | 38/21 | 0.747 |
| ISDR mutation (n = 0–1/2-) | 126/25 | 50/7 | 0.523 |
Data are shown as mean ± standard deviation. Figures in parentheses are the numbers of data available in each factor. Significant P values are shown in bold.
AFP, α-fetoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; FBS, fasting blood sugar; HCV, hepatitis C virus; IRI, immune-reactive insulin; ISDR, interferon-sensitivity determining region; LDL-C, low-density lipoprotein cholesterol; T.Bil, total bilirubin; T.Chol, total cholesterol; WBC, white blood cell; γ-GTP, γ-glutamyl transpeptidase.