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. 2014 Dec 11;10(12):e1003991. doi: 10.1371/journal.pcbi.1003991

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© 2014 Puszynski et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Black solid arrows: chemical reactions; red solid arrows: chemical reactions involving Nutlin; green dashed arrows: induction of activities; blue solid arrows: translocations. P, phosphate group; u, ubiquitin; n, Nutlin; the symbol denotes degradation.

Inline graphic — Black solid arrows: chemical reactions; red solid arrows: chemical reactions involving Nutlin; green dashed arrows: induction of activities; blue solid arrows: translocations. P, phosphate group; u, ubiquitin; n, Nutlin; the symbol denotes degradation.