. 2014 Dec 11;10(12):e1004801. doi: 10.1371/journal.pgen.1004801

Table 2. GWAS of metabolites associated with CHD; SNPs with P-value<5×10⁻⁷ and minor allele frequency > 5% are reported.

Metabolite	Chromosome	SNP	Position (build 37)	Nearest Gene	Effect/non- effect allele	Average Allele Frequency	Meta-analysis in the three studies (N = 3,620)^*		SNP Context
							OR	P-value
LysoPC 18∶1	8	rs75729820^†	94088655	C8orf87	T/C	0.95	1.34	2.7E-08	Intergenic
	22	rs8141918	43136583	A4GALT	A/G	0.70	1.14	4.5E-07	Intergenic
LysoPC 18∶2	11	rs174568	61593816	FADS2	T/C	0.35	1.15	8.4E-09	NearGene-5^‡
	8	rs2048797	115181070	CSMD3	A/T	0.70	1.14	4.4E-07	Intergenic
MG 18∶2	11	rs964184	116648917	ZNF259/APOA5	G/C	0.13	1.20	1.2E-07	NearGene-3^‡
SM 28∶1	14	rs12878001	64239629	SGPP1	G/T	0.15	1.21	1.2E-08	Intergenic
	1	rs113317091	32925064	ZBTB8B	T/C	0.13	1.20	1.9E-07	Intergenic

* Values are from fixed effect meta-analysis.

^†

Significant heterogeneity across studies (I² = 0.8).

^‡

The “Near Gene” region includes the mRNA region of the gene as well as arbitrary regions of 2K nucleotides upstream and 0.5K nucleotides downstream to allow for potential regulatory regions.

Table 2. GWAS of metabolites associated with CHD; SNPs with P-value<5×10−7 and minor allele frequency > 5% are reported.

Table 2. GWAS of metabolites associated with CHD; SNPs with P-value<5×10⁻⁷ and minor allele frequency > 5% are reported.